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Harmful Effects of NSAIDs among Patients with Hypertension and Coronary Artery Disease by Anthony A. Bavry; Asma Khaliq; Yan Gong; Eileen M. Handberg; Rhonda M. Cooper-DeHoff; Carl J. Pepine is a Medicine article available to read on EtoBox.

What is Harmful Effects of NSAIDs among Patients with Hypertension and Coronary Artery Disease about?

## Background: There is limited information about the safety of chronic nonsteroidal anti-inflammatory drugs (nsaids) in hypertensive patients with coronary artery disease. ## Methods: This was a post hoc analysis from the international verapamil trandolapril study (invest), which enrolled patients with hypertension and coronary artery disease. at each visit, patients were asked by the local site investigator if they were currently taking nsaids. patients who reported nsaid use at every visit were defined as chronic nsaid users, while all others (occasional or never users) were defined as nonchronic nsaid users. the primary composite outcome was all-cause death, nonfatal myocardial infarction, or nonfatal stroke. cox regression was used to construct a multivariate analysis for the primary outcome. ## Results: There were 882 chronic nsaid users and 21,694 nonchronic nsaid users (n = 14,408 for never users and n=7286 for intermittent users). at a mean follow-up of 2.7 years, the primary outcome occurred at a rate of 4.4 events per 100 patient-years in the chronic nsaid group, versus 3.7 events per 100 patient-years in the nonchronic nsaid group (adjusted hazard ratio [hr] 1.47; 95% c

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Author

Anthony A. Bavry; Asma Khaliq; Yan Gong; Eileen M. Handberg; Rhonda M. Cooper-DeHoff; Carl J. Pepine

Publisher

Elsevier BV

Published

2011

Language

EN

Field

Medicine (Health Sciences)