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Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases ζ/β as the putative F3 receptors on Schwann cells by Dimitra Thomaidou; Delphine Coquillat; Stathis Meintanis; Masaharu Noda; Genevieve Rougon; Rebecca Matsas is a Neuroscience article available to read on EtoBox.
What is Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases ζ/β as the putative F3 receptors on Schwann cells about?
Neural cell adhesion molecule (NCAM) and F3 are both axonal adhesion molecules which display homophilic (NCAM) or heterophilic (NCAM, F3) binding activities and participate in bidirectional exchange of information between neurones and glial cells. Engineered Fc chimeric molecules are fusion proteins that contain the extracellular part of NCAM or F3 and the Fc region of human IgG1. Here, we investigated the effect of NCAM‐Fc and F3‐Fc chimeras on Schwann cell (SC) migration. Binding sites were identified at the surface of cultured SCs by chimera coated fluorospheres. The functional effect of NCAM‐Fc and F3‐Fc binding was studied in two different SC migration models. In the first, migration is monitored at specific time intervals inside a 1‐mm gap produced in a monolayer culture of SCs. In the second, SCs from a dorsal root ganglion explant migrate on a sciatic nerve cryosection. In both systems addition of the chimeras significantly increased the extent of SC migration and this effect could be prevented by the corresponding anti‐NCAM or anti‐F3 blocking antibodies. Furthermore, antiproteoglycan‐type protein tyrosine phosphatase ζ/β (RPTPζ/β) antibodies identified the presence of RPT
Who reads Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases ζ/β as the putative F3 receptors on Schwann cells?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dimitra Thomaidou; Delphine Coquillat; Stathis Meintanis; Masaharu Noda; Genevieve Rougon; Rebecca Matsas
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)