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p21 Functions in Cell Cycle Regulation by rayanahfedan is a document available to read on EtoBox.

P21 is a protein that regulates the cell cycle, apoptosis, and transcriptional regulation after DNA damage. It functions as a CDK inhibitor, arresting the cell cycle in G1/S and G2/M transitions. P21 expression is mainly regulated by the tumor suppressor protein p53. It inhibits the cell cycle by binding and inhibiting CDK2/cyclin E and CDK1/cyclin complexes. P21 also plays a role in apoptosis and interacts with pathways like PI3K/Akt. Targeting factors upstream or downstream of P21, such as transcription f

Author

rayanahfedan

Language

EN