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Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development by Chenghua Gu; E.Rene Rodriguez; Dorothy V Reimert; Tianzhi Shu; Bernd Fritzsch; Linda J Richards; Alex L Kolodkin; David D Ginty is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development about?

Neuropilin-1 (Npn-1) is a receptor that binds multiple ligands from structurally distinct families, including secreted semaphorins (Sema) and vascular endothelial growth factors (VEGF). We generated npn-1 knockin mice, which express an altered ligand binding site variant of Npn-1, and npn-1 conditional null mice to establish the cell-type- and ligand specificity of Npn-1 function in the developing cardiovascular and nervous systems. Our results show that VEGF-Npn-1 signaling in endothelial cells is required for angiogenesis. In striking contrast, Sema-Npn-1 signaling is not essential for general vascular development but is required for axonal pathfinding by several populations of neurons in the CNS and PNS. Remarkably, both Sema-Npn-1 signaling and VEGF-Npn-1 signaling are critical for heart development. Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system.

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Author

Chenghua Gu; E.Rene Rodriguez; Dorothy V Reimert; Tianzhi Shu; Bernd Fritzsch; Linda J Richards; Alex L Kolodkin; David D Ginty

Publisher

Elsevier BV

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)