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Can I read Validity of Different Copeptin Assays in the Differential Diagnosis of the Polyuria-polydipsia Syndrome on EtoBox?
Validity of Different Copeptin Assays in the Differential Diagnosis of the Polyuria-polydipsia Syndrome by Sailer, Clara Odilia (author);Refardt, Julie (author);Blum, Claudine Angela (author);Schnyder, Ingeborg (author);Molina-Tijeras, Jose Alberto (author);Fenske, Wiebke (author);Christ-Crain, Mirjam (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Validity of Different Copeptin Assays in the Differential Diagnosis of the Polyuria-polydipsia Syndrome about?
The aim of this study was to correlate three commercially available copeptin assays and their diagnostic accuracy in the differential diagnosis of the polyuria-polydipsia syndrome. Analyzed data include repeated copeptin measures of 8 healthy volunteers and 40 patients with polyuria-polydipsia syndrome undergoing osmotic stimulation and of 40 patients hospitalized with pneumonia. Copeptin was measured using the automated Brahms KRYPTOR, the manual Brahms LIA and the manual Cloud Clone ELISA assay. Primary outcome was the interrater correlation coefficient (ICC) and diagnostic accuracy in the polyuria-polydipsia syndrome of the three assays. In healthy volunteers, there was a moderate correlation for the KRYPTOR and LIA (ICC 0.74; 95% CI 0.07 to 0.91), and a poor correlation for the KRYPTOR and ELISA (ICC 0.07; 95% CI − 0.06 to 0.29), as for the LIA and ELISA (ICC 0.04; 95% CI − 0.04 to 0.17). The KRYPTOR had the highest diagnostic accuracy (98% (95% CI 83 to100)), comparable to the LIA (88% (95% CI 74 to 100)), while the ELISA had a poor diagnostic accuracy (55% (95% CI 34 to 68)) in the differential diagnosis of the polyuria-polydipsia syndrome. The KRYPTOR and LIA yield comparabl
Who reads Validity of Different Copeptin Assays in the Differential Diagnosis of the Polyuria-polydipsia Syndrome?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sailer, Clara Odilia (author);Refardt, Julie (author);Blum, Claudine Angela (author);Schnyder, Ingeborg (author);Molina-Tijeras, Jose Alberto (author);Fenske, Wiebke (author);Christ-Crain, Mirjam (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)