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<br> Since the publication of <em>Protein Kinases</em> in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. <em>Protein Kinase Functions</em> is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updated and new topics covered in depth are: phosphatidylinositol 3-kinase signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGFß superfamily, and the involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individual kinases, but on the functional aspects of the whole system and the relationship between processes and molecules. It is the aim of <em>Protein Kinase Functions</em> to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and resp

Author

Woodgett, James Robert

Publisher

Oxford University Press, USA

Published

2000

Language

EN

ISBN

9780199637713

Subjects

Science, Chemistry, Medical