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Can I read Final Checkpoint in the Drug-promoted and Poliovirus-promoted Apoptosis Is Under Post-translational Control by Growth Factors on EtoBox?
Final Checkpoint in the Drug-promoted and Poliovirus-promoted Apoptosis Is Under Post-translational Control by Growth Factors by Elena A. Tolskaya; Lyudmila I. Romanova; Marina S. Kolesnikova; Tatiana A. Ivannikova; Vadim I. Agol is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Final Checkpoint in the Drug-promoted and Poliovirus-promoted Apoptosis Is Under Post-translational Control by Growth Factors about?
The treatment of HeLa subline (HeLa-B) cells with cycloheximide or Actinomycin D resulted in a rapid ( \* 1.5 h and -2.5 h, respectively) development of morphological and biochemical signs of apoptosis. The addition of fetal bovine serum to the cycloheximide-treated or Actinomycin D-treated cells suppressed the apoptotic reaction, as evidenced by the postponement of the DNA fragmentation for at least 9 and 5 h, respectively. A similar suppressive effect was observed upon the serum addition to cells undergoing abortive infection with poliovirus, which died of apoptosis in the absence of the serum. The serum appeared to exert its anti-apoptotic effect without any appreciablc lag and even immediately blocked further progress of ongoing DNA fragmentation. The epidermal growth factor also suppressed, although less efficiently and more transiently, the apoptotic reaction promoted by the metabolic inhibitors. It is concluded that growth factors may affect, without modulating either transcription or translation, the balance of pro-apoptotic and anti-apoptotic activities at a final checkpoint, just preceding the irreversible effector step of apoptosis. r 1996 wiiey-Liss, Inc
Who reads Final Checkpoint in the Drug-promoted and Poliovirus-promoted Apoptosis Is Under Post-translational Control by Growth Factors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Elena A. Tolskaya; Lyudmila I. Romanova; Marina S. Kolesnikova; Tatiana A. Ivannikova; Vadim I. Agol
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 1996
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)