Opening book details…
Can I read Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors on EtoBox?
Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors by Lina Zhu; Jing Jin; Chang Liu; Chongjing Zhang; Yan Sun; Yanshen Guo; Decai Fu; Xiaoguang Chen; Bailing Xu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors about?
A series of novel 2,4-disubstituted quinazoline derivatives were prepared and their inhibitory activities on hPin1 were evaluated. Of all the synthesized compounds, eight compounds displayed inhibitory activities with IC(50) value at the level of 10(-6)mol/L. Preliminary structure-activity relationships were analyzed in details and the binding mode of the titled compounds was predicted using FlexX algorithm. The design and optimization of novel small molecule Pin1 inhibitors will be guided by the results of this report.
Who reads Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lina Zhu; Jing Jin; Chang Liu; Chongjing Zhang; Yan Sun; Yanshen Guo; Decai Fu; Xiaoguang Chen; Bailing Xu
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)