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Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease by Patrick Schöffski; Frank Tacke; Christian Trautwein; Michael Uwe Martin; Martin Caselitz; Hartmut Hecker; Michael Peter Manns; Arnold Ganser is a Medicine article available to read on EtoBox.
What is Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease about?
**Abstract:** **Background/aims:** Thrombocytopenia in patients with advanced liver disease may stem from a deficient hepatic thrombopoietin production. **Methods:** We determined the relationship between thrombopoietin, thrombocytopenia, aetiology and extent of liver damage by incorporating serum thrombopoietin measurements in the pretransplant evaluation of 111 patients with liver disease. **Results:** The extent of thrombocytopenia was related to the underlying cause of disease. The platelet count directly correlated with factor V, II, fibrinogen, and PTT, and a negative correlation was found for splenic size and Child's stage. The thrombopoietin concentrations were age‐dependent, and no significant difference resulted between the median thrombopoietin level of liver disease patients with age‐matched healthy controls. Thrombopoietin concentrations and platelet counts were not correlated. Although noncirrhotic patients had higher platelet counts than those with Child's A–C cirrhosis (__p__ < 0.001, __U__‐test), no such difference was found in thrombopoietin levels. Patients with hepatitis B and/or C had lower platelet counts compared to patients with nonviral diseases (__p__ < 0.
Who reads Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease?
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- Author
- Patrick Schöffski; Frank Tacke; Christian Trautwein; Michael Uwe Martin; Martin Caselitz; Hartmut Hecker; Michael Peter Manns; Arnold Ganser
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0106-9543)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)