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Can I read Differential Influence of Azathioprine and Mycophenolate Mofetil on the Disposition of Basiliximab in Renal Transplant Patients on EtoBox?
Differential Influence of Azathioprine and Mycophenolate Mofetil on the Disposition of Basiliximab in Renal Transplant Patients by John M Kovarik; Mark D Pescovitz; Hans W Sollinger; Bruce Kaplan; Christophe Legendre; Kaija Salmela; Benita K Book; Christophe Gerbeau; Daniele Girault; Kenneth Somberg; on behalf of the Simulect Phase Iv Study Group is a Medicine article available to read on EtoBox.
What is Differential Influence of Azathioprine and Mycophenolate Mofetil on the Disposition of Basiliximab in Renal Transplant Patients about?
Pharmacokinetic sampling was performed in two multicenter trials in which basiliximab (anti‐CD25 monoclonal antibody) was administered with triple immunosuppression consisting of cyclosporine microemulsion, corticosteroids, and either azathioprine or mycophenolate mofetil. Blood samples were collected over 12 wk post‐transplant from 31 azathioprine‐treated and 66 mycophenolate mofetil‐treated patients. Empirical Bayes estimates of each patient's basiliximab disposition parameters were derived and the duration of CD25 saturation was estimated as the time over which serum concentrations exceeded 0.2 μg/mL as confirmed by flow cytometry measurements. Basiliximab clearance was 29±14 mL/h when coadministered with azathioprine and 18±8 mL/h with mycophenolate mofetil. Both were significantly lower compared with a clearance of 37±15 mL/h from a previous study of basiliximab with dual therapy (p<0.001). As a consequence of the lower clearance of basiliximab, the durations of CD25 saturation were prolonged in the presence of azathioprine (50±20 d; range, 13–84) and mycophenolate mofetil (59±17 d; range, 28–94) compared with dual therapy (36±14 d; range, 12–91). A total of 27 acute rejection
Who reads Differential Influence of Azathioprine and Mycophenolate Mofetil on the Disposition of Basiliximab in Renal Transplant Patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- John M Kovarik; Mark D Pescovitz; Hans W Sollinger; Bruce Kaplan; Christophe Legendre; Kaija Salmela; Benita K Book; Christophe Gerbeau; Daniele Girault; Kenneth Somberg; on behalf of the Simulect Phase Iv Study Group
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0063)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)