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Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium☆ by Susan D. Hester; Gina B. Benavides; Lawrence Yoon; Kevin T. Morgan; Fei Zou; William Barry; Douglas C. Wolf is a Environmental Science article available to read on EtoBox.

What is Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium☆ about?

Formaldehyde (FA), an occupational and environmental toxicant used extensively in the manufacturing of many household and personal use products, is known to induce squamous cell carcinomas in the nasal turbinates of rats and mice and squamous metaplasia in monkey noses. Tissue responses to FA include a dose dependent epithelial degeneration, respiratory cell hypertrophy, and squamous metaplasia. The primary target for FA-induced toxicity in both rodents and monkeys is the respiratory nasal epithelium. FA increases nasal epithelial cell proliferation and DNA-protein crosslinks (DPX) that are associated with subsequent nasal cancer development. To address the acute effects of FA exposure that might contribute to known pathological changes, cDNA gene expression analysis was used. Two groups of male F344 rats received either 40 ul of distilled water or FA (400 mM) instilled into each nostril. Twenty-four hours following treatment, nasal epithelium was recovered from which total RNA was used to generate cDNA probes. Significance analysis of microarrays (SAM) hybridization data using Clontech Rat Atlas 1.2 arrays revealed that 24 of the 1185 genes queried were significantly up-regulated

Who reads Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium☆?

Author

Susan D. Hester; Gina B. Benavides; Lawrence Yoon; Kevin T. Morgan; Fei Zou; William Barry; Douglas C. Wolf

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2003

Language

EN

Field

Environmental Science (Life Sciences)