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Pingchan granule for depressive symptoms in parkinson’s disease: A randomized, double-blind, placebo-controlled trial by Si-chun Gu; Jie Zhou; Qing Ye; Can-xing Yuan is a Medicine article available to read on EtoBox.

What is Pingchan granule for depressive symptoms in parkinson’s disease: A randomized, double-blind, placebo-controlled trial about?

## Background: Depression in parkinson's disease (dpd) is closely related to quality of life. current studies have suggested that pingchan granule (pcg) might be effective for treating dpd. ## Objective: This study determines the efficacy of pcg for depressive symptoms in parkinson's disease (pd). ## Design, setting, participants and interventions: This was a randomized, double-blind, placebo-controlled trial, conducted in longhua hospital, shanghai, china. patients diagnosed with idiopathic pd and clinically significant depressive symptoms (defined by a 24-item hamilton rating scale for depression [ham-d] score ≥ 8) were included in this study, randomly assigned to pcg or placebo group in a 1:1 ratio and followed for 24 weeks. ## Main outcome measures: The primary outcome was the change from baseline to week 24 in ham-d score among the set of patients who completed the study following the treatment protocol (per-protocol set). secondary outcomes included changes in scores on the unified parkinson's disease rating scale (updrs) part 2 (updrs-ii), updrs part 3 (updrs-iii), parkinson's disease sleep scale (pdss) and hamilton rating scale for anxiety (ham-a), between baseline and week

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Author

Si-chun Gu; Jie Zhou; Qing Ye; Can-xing Yuan

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)