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Wound Epithelialization Deficits in the Transforming Growth Factor-α Knockout Mouse by Injoong Kim; Jon E Mogford; Jerome D Chao; Thomas A Mustoe is a Medicine article available to read on EtoBox.

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In vitro, transforming growth factor‐α is an important factor controlling epithelial cell proliferation and migration. However, the transforming growth factor‐α knockout mouse has shown no wound epithelialization defect in tail amputation and full‐thickness back wounds. To resolve this disparity, we combined a full‐thickness head wound and a partial‐thickness ear wound on the transforming growth factor‐α knockout mouse for analysis of wound epithelialization with or without granulation tissue formation. Three‐millimeter ear wounds were made on the transforming growth factor‐α knockout and heterozygous control mice. Full‐thickness head wounds were made using a 6‐mm trephine on the crown of the skull. In the ear model, transforming growth factor‐α knockout mice had significantly larger epithelial gaps versus control at post‐operative day 3 and 5. Epithelial thickness at the wound edge of transforming growth factor‐α deficient mice was also depressed at post‐operative day 3 and post‐operative day 5 compared to control mice. On post‐operative day 8, most wounds of both groups were epithelialized. In contrast, no difference in epithelial gap or new granulation tissue was found in the he

Who reads Wound Epithelialization Deficits in the Transforming Growth Factor-α Knockout Mouse?

Author

Injoong Kim; Jon E Mogford; Jerome D Chao; Thomas A Mustoe

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1067-1927)

Published

2001

Language

EN

Field

Medicine (Health Sciences)