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Focusing on Powder Processing in Dry Powder Inhalation Product Development, Manufacturing and Performance by Sven Stegemann; Eva Faulhammer; Joana T Pinto; Amrit Paudel is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Focusing on Powder Processing in Dry Powder Inhalation Product Development, Manufacturing and Performance about?

Dry powder inhalers (DPI) are well established products for the delivery of actives via the pulmonary route. Various DPI products are marketed or developed for the treatment of local lung diseases such as chronic obstructive pulmonary disease (COPD), asthma or cystic fibrosis as well as systemic diseases targeted through inhaled delivery (i.e. Diabetes Mellitus). One of the key prerequisites of DPI formulations is that the aerodynamic size of the drug particles needs to be below 5 μm to enter deeply into the respiratory tract. These inherently cohesive inhalable size particles are either formulated as adhesive mixture with coarse carrier particles like lactose called carrier-based DPI or are formulated as free-flowing carrier-free particles (e.g. soft agglomerates, large hollow particles). In either case, it is common practice that drug and/or excipient particles of DPI formulations are obtained by processing API and API/excipients. The DPI manufacturing process heavily involves several particle and powder technologies such as micronization of the API, dry blending, powder filling and other particle engineering processes such as spray drying, crystallization etc. In this context, i

Who reads Focusing on Powder Processing in Dry Powder Inhalation Product Development, Manufacturing and Performance?

Author

Sven Stegemann; Eva Faulhammer; Joana T Pinto; Amrit Paudel

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)