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Can I read Delivery of Genome-editing Biomacromolecules for Treatment of Lung Genetic Disorders on EtoBox?
Delivery of Genome-editing Biomacromolecules for Treatment of Lung Genetic Disorders by Tao Wan; Yuan Ping is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Delivery of Genome-editing Biomacromolecules for Treatment of Lung Genetic Disorders about?
Genome-editing systems based on clustered, regularly interspaced, short palindromic repeat (CRISPR)/associated protein (CRISPR/Cas), are emerging as a revolutionary technology for the treatment of various genetic diseases. To date, the delivery of genome-editing biomacromolecules by viral or non-viral vectors have been proposed as new therapeutic options for lung genetic disorders, such as cystic fibrosis (CF) and α-1 antitrypsin deficiency (AATD), and it has been accepted that these delivery vectors can introduce CRISPR/Cas9 machineries into target cells or tissues in vitro, ex vivo and in vivo. However, the efficient local or systemic delivery of CRISPR/Cas9 elements to the lung, enabled by either viral or by non-viral carriers, still remains elusive. Herein, we first introduce lung genetic disorders and their current treatment options, and then summarize CRISPR/Cas9-based strategies for the therapeutic genome editing of these disorders. We further summarize the pros and cons of different routes of administration for lung genetic disorders. In particular, the potentials of aerosol delivery for therapeutic CRISPR/Cas9 biomacromolecules for lung genome editing are discussed and hig
Who reads Delivery of Genome-editing Biomacromolecules for Treatment of Lung Genetic Disorders?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tao Wan; Yuan Ping
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)