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Diagnostic values of proenkephalin and S100B protein in traumatic brain injury by Anil Yalcin; Ahmet Baydin; Özgür Korhan Tuncel; Ali Kemal Erenler; Cengiz Çokluk; Murat Güzel; Leman Tomak is a Medicine article available to read on EtoBox.

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## Abstract ## Background: The primary aim of this study was to investigate the diagnostic values of serum S100 calcium-binding protein B (S100B) and proenkephalin (P-ENK) levels in brain damage caused by traumatic brain injury (TBI). ## Methods: We prospectively collected serum blood samples of 58 adult patients admitted to our emergency department due to TBI. Serum S100B and P-ENK levels were measured and compared according to clinical findings and outcomes of the patients. ## Results: When patients with brain injury were compared to controls, statistical significance was determined in both S100B and P-ENK levels. According to the receiver operating characteristic (ROC) analysis, cut-off values for serum S100B and P-ENK levels for the differential diagnosis of patients with and without brain damage were found to be 785.944 ng/mL and 2.445 ng/mL, respectively. There was a statistical significance in both S100B and P-ENK levels when patients who were discharged and those who died were compared. ## Conclusions: Serum S100B and P-ENK levels are found to be elevated in patients with TBI when compared to controls. Additionally, serum levels of both markers are found to be elevated in p

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Author

Anil Yalcin; Ahmet Baydin; Özgür Korhan Tuncel; Ali Kemal Erenler; Cengiz Çokluk; Murat Güzel; Leman Tomak

Publisher

Walter de Gruyter GmbH

Published

2017

Language

EN

Field

Medicine (Health Sciences)