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Impairment of eyeblink conditioning in GluRδ2-mutant mice depends on the temporal overlap between conditioned and unconditioned stimuli by Yasushi Kishimoto; Shigenori Kawahara; Ryoko Fujimichi; Hisashi Mori; Masayoshi Mishina; Yutaka Kirino is a Neuroscience article available to read on EtoBox.

What is Impairment of eyeblink conditioning in GluRδ2-mutant mice depends on the temporal overlap between conditioned and unconditioned stimuli about?

## Abstract Mice lacking the glutamate receptor subunit δ2 (GluRδ2) are deficient in cerebellar long‐term depression (LTD) at the parallel fibre–Purkinje cell synapses. We conducted delay and trace eyeblink conditioning with these mice, using various temporal intervals between the conditioned stimulus (CS) and unconditioned stimulus (US). During trace conditioning in which a stimulus‐free trace interval (TI) of 250, 100 or 50 ms intervened between the 352‐ms tone CS and 100‐ms US, GluRδ2‐mutant mice learned as successfully as wild‐type mice. Even in the paradigm with TI = 0 ms, in which the end of CS and onset of US are simultaneous, there was no difference between the GluRδ2‐mutant and wild‐type mice in their acquisition of a conditioned response. However, in the delay paradigm in which the 452‐ms CS overlapped temporally with the coterminating 100‐ms US, GluRδ2‐mutant mice exhibited severe learning impairment. The present study together with our previous work [Kishimoto, Y., Kawahara, S., Suzuki, M., Mori, H., Mishina, M. & Kirino, Y. (2001) __Eur. J. Neurosci.,__**13**, 1249–1254], indicates that cerebellar LTD‐independent learning is possible in paradigms without temporal overl

Who reads Impairment of eyeblink conditioning in GluRδ2-mutant mice depends on the temporal overlap between conditioned and unconditioned stimuli?

Author

Yasushi Kishimoto; Shigenori Kawahara; Ryoko Fujimichi; Hisashi Mori; Masayoshi Mishina; Yutaka Kirino

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2001

Language

EN

Field

Neuroscience (Life Sciences)