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Preparation of pH-sensitive alginate-based hydrogel by microfluidic technology for intestinal targeting drug delivery by Shishuai Qiao; Weinan Chen; Xiaoguang Zheng; Li Ma is a Materials Science article available to read on EtoBox.

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## A C T Hydrogel microspheres stand out in drug delivery due to their small particle size, biocompatibility and good internal stability. In this paper, pH-sensitive hydrogels are prepared by microfluidic technology for targeted drug delivery in the small intestine. A coaxial dual-channel microfluidic chip is constructed. By analyzing the effects of flow rates and three fracture stages (Rayleigh-Plateau instability crushing stage, pressure difference crushing stage and shear force crushing stage) on the size of hydrogel microspheres, the optimal control stage of the microsphere size is determined (shear force crushing stage). Based on this, the accurate control model of the hydrogel microsphere size is proposed. In addition, based on the coaxial dual channel microfluidic chip, a monolayer hydrogel microcapsule loaded with Indometacin is prepared. The core-shell hydrogel microcapsules loaded with Indometacin are prepared by an improved coaxial three channel microfluidic chip. The swelling rates of both microcapsules in simulated intestinal fluid are significantly higher than those in simulated gastric fluid. The results of in vitro simulated release experiments show that the two hyd

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Author

Shishuai Qiao; Weinan Chen; Xiaoguang Zheng; Li Ma

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Materials Science (Physical Sciences)