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What is Synthesis of Curcumin Analogues for Cancer about?

Novel asymmetrical monocarbonyl analogues of curcumin (asymmetrical MACs) were synthesized via Claisen-Schmidt condensation reactions between various aldehydes and cyclohexanone. Six compounds were purified and characterized using analytical techniques. Cytotoxicity testing showed all compounds had LC50 values less than 1000 μg/mL, indicating potential as anti-carcinogenic agents like curcumin. Yield ranged from 2.7% to 55.53% for the compounds synthesized.

Author

Pekik Wiji Prasetyaningrum

Language

EN