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Treatment of children with acute lymphoblastic leukemia in India using a BFM protocol by Ashish Bajel; Biju George; Vikram Mathews; Auro Viswabandya; M.L. Kavitha; Alok Srivastava; Mammen Chandy is a Medicine article available to read on EtoBox.

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## Abstract ## Background Limited data exists on the long‐term treatment outcome and prognosis of childhood ALL in India. ## Procedure Three hundred and seven children (1–14 years) with acute lymphoblastic leukemia (ALL) were treated with a modified BFM protocol 76/79 between 1985 and 2003. Treatment outcome and prognostic factors were evaluated. ## Results The median age was 6 years; 78% had B lineage acute lymphoblastic leukemia and 22% had T lineage disease. Good prednisolone response was observed in 82% of cases. Two hundred and seventy‐three children (91.6%) achieved complete remission; with 2% induction‐related mortality and 6.4% having resistant disease. 52% of all evaluable patients and 56.8% of complete responders are in continuous complete remission (CCR) at a median follow up of 62 months (30–194 months). The median event free survival (EFS) was 114 months. The estimated 5 year overall survival, EFS and disease free survival was 59.8%, 56%, and 53.9%, respectively. The prognostic factors adversely affecting the EFS were poor prednisolone response, resistant disease and WBC count greater than 20 × 10^9^/L at diagnosis. The 5 year EFS in the favorable risk group (age 1–9 y

Who reads Treatment of children with acute lymphoblastic leukemia in India using a BFM protocol?

Author

Ashish Bajel; Biju George; Vikram Mathews; Auro Viswabandya; M.L. Kavitha; Alok Srivastava; Mammen Chandy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2008

Language

EN

Field

Medicine (Health Sciences)