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Can I read Characterization of the Solubility and Solid-state Properties of Saccharin Salts of Fluoroquinolones on EtoBox?
Characterization of the Solubility and Solid-state Properties of Saccharin Salts of Fluoroquinolones by Carolina B. Romañuk; Ruben H. Manzo; Yamila Garro Linck; Ana K. Chattah; Gustavo A. Monti; Maria E. Olivera is a Chemistry article available to read on EtoBox.
What is Characterization of the Solubility and Solid-state Properties of Saccharin Salts of Fluoroquinolones about?
Saccharinates salts of the fluoroquinolone antibiotics norfloxacin, ciprofloxacin, ofloxacin, and enrofloxacin were obtained as pure crystalline anhydrous solids with sweet taste. The products were characterized by one- ((13)C) and two-dimensional ((1)H-(13)C) dimensions solid state Nuclear Magnetic Resonance and infrared spectroscopy showing ionic interactions between the saccharine amide and the fluoroquinolone piperazine. Several intermolecular bindings were also identified. Thermal behavior and powder X-ray diffraction provided complementary evidences of salt formation. The series of products showed improved properties with respect to water solubility. A solubility model was developed. These salts would be a good way forward to developing more suitable formulations of these APIs.
Who reads Characterization of the Solubility and Solid-state Properties of Saccharin Salts of Fluoroquinolones?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Carolina B. Romañuk; Ruben H. Manzo; Yamila Garro Linck; Ana K. Chattah; Gustavo A. Monti; Maria E. Olivera
- Publisher
- Elsevier BV
- Published
- 2009
- Language
- EN
- Field
- Chemistry (Physical Sciences)