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KIT immunohistochemistry and mutation status in gastrointestinal stromal tumours (GISTs) evaluated for treatment with imatinib by M B Loughrey; M Trivett; V Beshay; A Dobrovic; S Kovalenko; W Murray; S Lade; H Turner; G A McArthur; J Zalcberg; P M Waring is a Medicine article available to read on EtoBox.

What is KIT immunohistochemistry and mutation status in gastrointestinal stromal tumours (GISTs) evaluated for treatment with imatinib about?

**Aims** : With the availability of effective but expensive treatment in the form of imatinib, accurate diagnosis of gastrointestinal stromal tumour (GIST) is extremely important. The aims of this study were: to describe the clinicopathological, immunohistochemical and molecular features of cases referred to a cancer centre with a possible diagnosis of GIST; to identify pitfalls in the performance and interpretation of KIT immunohistochemistry; to define the role of __KIT__ mutation testing in making a diagnosis of GIST. **Methods and results** : Morphological review, KIT immunohistochemistry and mutation testing were performed on all cases referred with a diagnosis of GIST or where the diagnosis was under serious consideration on the basis of KIT immunopositivity with a view to treating with imatinib. Thirty‐seven cases met the inclusion criteria. Of these, 26 were classified as GIST and 11 as non‐GIST. Most GISTs showed strong diffuse membranous, cytoplasmic or paranuclear KIT immunopositivity. Some non‐GISTs demonstrated patchy cytoplasmic KIT immunopositivity related to the immunohistochemical protocol used in the external laboratory, which led to erroneous diagnoses of GIST in

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Author

M B Loughrey; M Trivett; V Beshay; A Dobrovic; S Kovalenko; W Murray; S Lade; H Turner; G A McArthur; J Zalcberg; P M Waring

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0309-0167)

Published

2006

Language

EN

Field

Medicine (Health Sciences)