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Can I read Off‐Label, but on‐Evidence? A Review of the Level of Evidence for Pediatric Pharmacotherapy on EtoBox?
Off‐Label, but on‐Evidence? A Review of the Level of Evidence for Pediatric Pharmacotherapy by Tjitske M. van der Zanden; Nori J.L. Smeets; Marika de Hoop‐Sommen; Michiel F.T. Schwerzel; Hui Jun Huang; Lieke J.C. Barten; Joyce E.M. van der Heijden; Jolien J.M. Freriksen; Akira A.L. Horstink; Inge H.G. Holsappel; Miriam G. Mooij; Matthijs de Hoog; Saskia N. de Wildt is a Medicine article available to read on EtoBox.
What is Off‐Label, but on‐Evidence? A Review of the Level of Evidence for Pediatric Pharmacotherapy about?
Many drugs are still prescribed off‐label to the pediatric population. Although off‐label drug use not supported by high level of evidence is potentially harmful, a comprehensive overview of the quality of the evidence pertaining off‐label drug use in children is lacking. The Dutch Pediatric Formulary (DPF) provides best evidence‐based dosing guidelines for drugs used in children. For each drug‐indication‐age group combination—together compiling one record—we scored the highest available level of evidence: labeled use, systematic review or meta‐analysis, randomized controlled trial (RCT), comparative research, noncomparative research, or consensus‐based expert opinions. For records based on selected guidelines, the original sources were not reviewed. These records were scored as guideline. A total of 774 drugs were analyzed comprising a total of 6,426 records. Of all off‐label records (__n__ = 2,718), 14% were supported by high quality evidence (4% meta‐analysis or systematic reviews, 10% RCTs of high quality), 20% by comparative research, 14% by noncomparative research, 37% by consensus‐based expert opinions, and 15% by selected guidelines. Fifty‐eight percent of all records were
Who reads Off‐Label, but on‐Evidence? A Review of the Level of Evidence for Pediatric Pharmacotherapy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tjitske M. van der Zanden; Nori J.L. Smeets; Marika de Hoop‐Sommen; Michiel F.T. Schwerzel; Hui Jun Huang; Lieke J.C. Barten; Joyce E.M. van der Heijden; Jolien J.M. Freriksen; Akira A.L. Horstink; Inge H.G. Holsappel; Miriam G. Mooij; Matthijs de Hoog; Saskia N. de Wildt
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)