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Implementation And Outcomes Of Dolutegravir-based First-line Antiretroviral Therapy For People With Hiv In South Africa: A Retrospective Cohort Study by Jienchi Dorward; Yukteshwar Sookrajh; Thokozani Khubone; Johan van der Molen; Riona Govender; Sifiso Phakathi; Lara Lewis; Christian Bottomley; Munthra Maraj; Richard J Lessells; Kogieleum Naidoo; Christopher C Butler; Rose Van Heerden; Nigel Garrett is a Medicine article available to read on EtoBox.

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## Background There is little data evaluating uptake of first-line dolutegravir among men and women living with HIV in low- and middle-income countries, and subsequent clinical outcomes in non-trial settings. We aimed to determine dolutegravir uptake in women, and the impact of dolutegravir on clinical outcomes in routine care in South Africa. ## Methods We analysed de-identified data from adults receiving first-line ART at 59 South African clinics from December 2019 to February 2022, using two distinct cohorts. In the ‘initiator cohort’, we used Poisson regression models to assess initiation with dolutegravir-based ART by gender, and associations between dolutegravir use and 12-month retention-in-care and viral suppression <50 copies/mL. In the ‘transition cohort’, consisting of adults receiving non-dolutegravir-based first-line ART in December 2019, we used Cox proportional hazards models to assess the hazard of transition to first-line dolutegravir by gender. We then used time-dependent propensity score matching to compare subsequent 12-month retention-in-care and viral suppression between people transitioned to dolutegravir, and those who had not yet transitioned at the same ti

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Author

Jienchi Dorward; Yukteshwar Sookrajh; Thokozani Khubone; Johan van der Molen; Riona Govender; Sifiso Phakathi; Lara Lewis; Christian Bottomley; Munthra Maraj; Richard J Lessells; Kogieleum Naidoo; Christopher C Butler; Rose Van Heerden; Nigel Garrett

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)