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Rhabdomyosarcoma of the larynx in children: A series of five patients treated in the Institut Gustave Roussy (Villejuif, France) by Mara A. D. P. Kato; Françoise Flamant; Marie José Terrier-Lacombe; Jean-Louis Habrand; Guy Schwaab; Bernard Luboinski; Dominique Valteau-Couanet; Jean Lemerle is a Medicine article available to read on EtoBox.

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Rhabdomyosarcoma of the larynx is a malignant disease rarely seen in children. We present five cases (3 males, 2 females) observed among 126 patients with rhabdomyosarcoma of the head and neck (excluding the orbit) treated in the Institut Gustave-Roussy between 1955 and 1981. The patients were aged between 5 1/2 years and 13 1/2 years at the time of diagnosis. The presenting symptoms were dysphonia and/or dyspnea; tracheotomy was required in two cases. All five patients received chemotherapy consisting of vincristine, cyclophosphamide, actinomycin D + procarbazine or doxorubicin. Four patients also received radiotherapy (45 Gy during 5 weeks). Laryngectomy was not performed. Treatment sequelae included regional hypoplasia, huskiness, and subclinical thyroid insufficiency; two patients developed a benign thyroid adenoma. One patient presented a bilateral carotid stenosis subsequent to radiotherapy performed on "wide fields" portal designed to provided prophylactic treatment on uninvolved lymph nodes. All the patients are alive and relapse-free with a follow-up of between 13 and 17 years. This small series of RMS of the larynx shows that patients can be cured without laryngectomy, al

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Author

Mara A. D. P. Kato; Françoise Flamant; Marie José Terrier-Lacombe; Jean-Louis Habrand; Guy Schwaab; Bernard Luboinski; Dominique Valteau-Couanet; Jean Lemerle

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)

Published

1990

Language

EN

Field

Medicine (Health Sciences)