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Biomimetic aminoated mesoporous silica xerogel exhibiting chiral surface topology for delivery insoluble drug with multiple-controlled manners and improved oral adsorption 1 1 Introduction 2 2 Materials and methods 2 2.1 Chemicals and reagents 2 2.2 Synthesis of L/d-BPEIN-MSX 3 2.2.1 Preparation of L/D-BPEI agglutination solution 3 2.2.2 Preparation of L/d-BPEIN-MSX 3 2.3 Synthesis of IMC-L/d-BPEIN-MSX 3 2.4 Structural characterization 3 2.4.1 Zeta potential 3 2.4.2 Circular dichroism spectrum 3 2.4.3 Fourier-transform infrared spectroscopy studies 3 2.4.4 Transmission electron microscopy studies 3 2.4.5 Scanning electron microscopy studies 3 2.4.6 Surface area and pore distribution analysis 3 2.4.7 Differential scanning calorimetry analysis 3 2.4.8 Powder X-ray diffraction studies 3 2.5 Wettability measurement 3 2.6 In vitro release study 3 2.7 Bio-adhesion study 4 2.8 Pharmacokinetic experiments 4 2.9 anti-inflammatory pharmacodynamics study 4 2.10 Gastrointestinal irritation test 4 2.11 Biodegradablity study 4 2.12 Hemocompatibility study 5 2.13 In vitro toxicity test 5 2.14 In vivo toxicity test 5 2.15 Statistical analysis 5 3 Results and discussion 5 3.1 Preparation and format

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Language

UND

Category

nonfiction