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The extract of Prunus persica flesh (PPFE) attenuates chemotherapy‐induced hepatotoxicity in mice by Chang Ki Lee; Kwang Kyun Park; Jae Kwan Hwang; Sang Kook Lee; Won Yoon Chung is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Cisplatin (__cis__‐diamminedichloroplatinum II) is one of the most effective chemotherapeutic agents used in the treatment of a variety of human solid tumors. However, its clinical use is limited due to severe toxicity. The pathogenesis of liver damage caused by cisplatin is generally considered to be oxidative damage. The aim of this study was to evaluate the protective effect of the ethanol extract of __Prunus persica__ flesh (PPFE) against cisplatin‐induced hepatotoxicity in animal models. In a xenograft model with the repeated administration of a low‐dose cisplatin (5 mg/kg body weight) for 15 days, and in an acute toxicity model with a single administration of a high‐dose cisplatin (45 mg/kg body weight) over a 16 h period, the consecutive administration of PPFE in combination with and prior to the cisplatin injection reversed the cisplatin‐induced decrease in the liver weight as a percentage of total body weight, and the cisplatin‐induced increases in the serum alanine aminotransferase and aspartate aminotransferase levels caused by liver damage. Moreover, the oral administration of PPFE significantly recovered the reduced glutathione level and inhibited lipid per

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Author

Chang Ki Lee; Kwang Kyun Park; Jae Kwan Hwang; Sang Kook Lee; Won Yoon Chung

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)