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Targeting SET-PP2A in KMT2A-R AML by ajana897264 is a document available to read on EtoBox.
What is Targeting SET-PP2A in KMT2A-R AML about?
The study identifies the SET-PP2A complex as a novel therapeutic target in KMT2A-rearranged acute myeloid leukemia (AML), which is aggressive and often resistant to chemotherapy. SET is found to be overexpressed in KMT2A-R leukemia, correlating with poor prognosis and the expression of key oncogenes, and its silencing impairs the clonogenic ability of leukemic cells. Pharmacological inhibition of SET enhances sensitivity to chemotherapy, suggesting that targeting SET could provide a new treatment strategy f
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- ajana897264
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- EN