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Heterogeneous Partition of Cellular Blood-borne Nanoparticles Through Microvascular Bifurcations by Liu, Zixiang L.; Clausen, Jonathan R.; Wagner, Justin L.; Butler, Kimberly S.; Bolintineanu, Dan S.; Lechman, Jeremy B.; Rao, Rekha R.; Aidun, Cyrus K. is a scholarly article available to read on EtoBox.

What is Heterogeneous Partition of Cellular Blood-borne Nanoparticles Through Microvascular Bifurcations about?

Blood flowing through microvascular bifurcations has been an active research topic for many decades, while the partitioning pattern of nanoscale solutes in the blood remains relatively unexplored. Here, we demonstrate a multiscale computational framework for direct numerical simulation of the nanoparticle (NP) partitioning through physiologically-relevant vascular bifurcations in the presence of red blood cells (RBCs). The computational framework is established by embedding a newly-developed particulate suspension inflow/outflow boundary condition into a multiscale blood flow solver. The computational framework is verified by recovering a tubular blood flow without a bifurcation and validated against the experimental measurement of an intravital bifurcation flow. The classic Zweifach-Fung (ZF) effect is shown to be well captured by the method. Moreover, we observe that NPs exhibit a ZF-like heterogeneous partition in response to the heterogeneous partition of the RBC phase. The NP partitioning prioritizes the high-flow-rate daughter branch except for extreme (large or small) suspension flow partition ratios under which the complete phase separation tends to occur. By analyzing the

Author

Liu, Zixiang L.; Clausen, Jonathan R.; Wagner, Justin L.; Butler, Kimberly S.; Bolintineanu, Dan S.; Lechman, Jeremy B.; Rao, Rekha R.; Aidun, Cyrus K.

Published

2020

Language

EN