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Barrett’s Oesophagus, Dysplasia and Pharmacologic Acid Suppression by R. C. Fitzgerald; R. Lascar; G. Triadafilopoulos is a Medicine article available to read on EtoBox.

What is Barrett’s Oesophagus, Dysplasia and Pharmacologic Acid Suppression about?

Barrett’s oesophagus, a significant complication of gastro‐oesophageal reflux disease (GERD), is the single most important risk factor for oesophageal adenocarcinoma. The strong association between Barrett’s oesophagus and chronic GERD suggests that abnormal oesophageal acid exposure plays an important role in this condition. The progression of Barrett’s oesophagus from specialized intestinal metaplasia to dysplasia and finally invasive carcinoma is incompletely understood, but increased and disordered proliferation is a key cellular event. In __ex vivo__ organ culture experiments, cell proliferation is increased after exposure to short pulses of acid, whilst proliferation is reduced in Barrett’s oesophagus specimens taken from patients with oesophageal acid exposure normalized by antisecretory therapy. In long‐term clinical studies, consistent and profound intra‐oesophageal acid suppression with proton pump inhibitors decreases cell proliferation and increases differentiation in Barrett’s oesophagus, but the clinical importance of such favourable effects on these surrogate markers is not clear. In clinical practice, proton pump inhibitors relieve symptoms and induce partial regres

Who reads Barrett’s Oesophagus, Dysplasia and Pharmacologic Acid Suppression?

Author

R. C. Fitzgerald; R. Lascar; G. Triadafilopoulos

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2001

Language

EN

Field

Medicine (Health Sciences)