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Combined analysis of PHOX2B at two time points and its value for further risk stratification in high‐risk neuroblastoma by Zhixia Yue; Chao Gao; Tianyu Xing; Wen Zhao; Chao Duan; Xisi Wang; Mei Jin; Yan Su is a Medicine article available to read on EtoBox.

What is Combined analysis of PHOX2B at two time points and its value for further risk stratification in high‐risk neuroblastoma about?

Background: Risk stratification of high-risk neuroblastoma (NB) is crucial for exploring treatments. This study aimed to explore the value of minimal residual disease (MRD) based on PHOX2B levels for further risk stratification in high-risk NB. Methods: The expression of PHOX2B was monitored at two time points (after two and six cycles of induction chemotherapy, TP1 and TP2, respectively) by real-time polymerase chain reaction (RT-PCR). The clinical characteristics between groups and survival rates were analyzed. Results: The study included 151 high-risk patients. Positive expression of PHOX2B at diagnosis was seen in 129 cases. PHOX2B was mainly expressed in patients with high lactate dehydrogenase (LDH) and neuron-specific enolase (NSE) levels (p < .001), bone marrow metastasis (p < .001), more than three metastatic organs (p < .001), 11q23 loss of heterozygosity (LOH) (p = .007), and when more events occurred (p = .012). The 4-year EFS rate was significantly lower in patients with positive PHOX2B expression compared to the negative group at diagnosis (32.9% ± 6.2% vs. 74.5% ± 10.1%, p = .005). We stratified the 151 patients into three MRD risk groups: low high-risk (low-HR), wit

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Author

Zhixia Yue; Chao Gao; Tianyu Xing; Wen Zhao; Chao Duan; Xisi Wang; Mei Jin; Yan Su

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)