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Hypothesis: a Possible Role for Mast Cells and Their Inflammatory Mediators in the Pathogenesis of Autoimmune Encephalomyelitis by B.F. Bebo Jr.; T. Yong; E.L. Orr; D.S. Linthicum is a Neuroscience article available to read on EtoBox.

What is Hypothesis: a Possible Role for Mast Cells and Their Inflammatory Mediators in the Pathogenesis of Autoimmune Encephalomyelitis about?

Mast cells and their potent chemical mediators are known to initiate and modulate a number of important inflammatory cascades. With respect to the central nervous system, the role of mast cells as participants in the promotion and resolution of inflammation has been widely underestimated. Mast cell-derived histamine, serotonin, kallikreins, and tumor necrosis factor-a (TNF-a) can enhance microvascular permeability, leukocyte rolling, adhesion, and extravasation of inflammatory cells into the brain and spinal cord. Mast cell mediators may play an important role in autoimmune encephalomyelitis and multiple sclerosis by promoting the entry of autoreactive T cells and the recruitment of nonspecific monocytes across the blood:brain barrier. 0 1996

Who reads Hypothesis: a Possible Role for Mast Cells and Their Inflammatory Mediators in the Pathogenesis of Autoimmune Encephalomyelitis?

Author

B.F. Bebo Jr.; T. Yong; E.L. Orr; D.S. Linthicum

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)