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Electrospun Homogeneous Silk Fibroin/poly (ɛ-Caprolactone) Nanofibrous Scaffolds by Addition of Acetic Acid for Tissue Engineering by Jiang Zhu; Jingjing Luo; Xingyan Zhao; Junjiu Gao; Jie Xiong is a Engineering article available to read on EtoBox.

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In this study, we investigated the phase separation phenomenon of silk fibroin/poly (ɛ-caprolactone) electrospinning solution to improve the performance of silk fibroin/poly (ɛ-caprolactone) electrospun nanofibers. It showed that phase separation does occur in just a few hours in the silk fibroin/poly (ɛ-caprolactone)/formic acid mixture solution. Acetic acid, small molecule nonsolvent for silk fibroin, was first introduced to silk fibroin/poly (ɛ-caprolactone)/formic acid solution, a homogeneous solution without separation for over several days was achieved after mixing for 5 h. The morphology and composition of the silk fibroin/poly (ɛ-caprolactone) and acetic acid-modified silk fibroin/poly (ɛ-caprolactone) fibrous scaffolds were examined by scanning electron microscopy, Fourier transform infrared spectroscopy and thermal gravimetric analyzer. Attachment and proliferation of mouse osteoblast MC3T3-E1 cells were tested by scanning electron microscopy and cytotoxity assay. The results indicated that the phase separation of silk fibroin/poly (ɛ-caprolactone) solution might led to inhomogeneous morphology and composition of the composite scaffolds, and the inhomogeneity of the silk

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Author

Jiang Zhu; Jingjing Luo; Xingyan Zhao; Junjiu Gao; Jie Xiong

Publisher

SAGE Publications

Published

2016

Language

EN

Field

Engineering (Physical Sciences)