Opening book details…
Can I read Lipid-Like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells on EtoBox?
Lipid-Like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells by Seung-Woo Cho; Michael Goldberg; Sun Mi Son; Qiaobing Xu; Fan Yang; Ying Mei; Said Bogatyrev; Robert Langer; Daniel G. Anderson is a Engineering article available to read on EtoBox.
What is Lipid-Like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells about?
## Abstract Here, nanoparticles composed of lipid‐like materials (lipidoids) to facilitate non‐viral delivery of small interfering RNA (siRNA) to endothelial cells (ECs) are developed. Nanoparticles composed of siRNA and lipidoids with small size (∼200 nm) and positive charge (∼34 mV) are formed by self‐assembly of lipidoids and siRNA. Ten lipidoids are synthesized and screened for their ability to facilitate the delivery of siRNA into ECs. Particles composed of leading lipidoids show significantly better delivery to ECs than a leading commercially available transfection reagent, Lipofectamine 2000. As a model of potential therapeutic application, nanoparticles composed of the top performing lipidoid, NA114, are studied for their ability to deliver siRNA targeting anti‐angiogenic factor (SHP‐1) to human ECs. Silencing of SHP‐1 expression significantly enhances EC proliferation and decreases EC apoptosis under a simulated ischemic condition.
Who reads Lipid-Like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Seung-Woo Cho; Michael Goldberg; Sun Mi Son; Qiaobing Xu; Fan Yang; Ying Mei; Said Bogatyrev; Robert Langer; Daniel G. Anderson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1616-301X)
- Published
- 2009
- Language
- EN
- Field
- Engineering (Physical Sciences)