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Microbiological Decontamination of Botanical Raw Materials and Corresponding Pharmaceutical Products by Irradiation by Branka Katušin-Ražem; Boris Novak; Dušan Ražem is a Materials Science article available to read on EtoBox.

What is Microbiological Decontamination of Botanical Raw Materials and Corresponding Pharmaceutical Products by Irradiation about?

Microbiological contamination typical of botanical raw materials used in the manufacture of pharmaceuticals decreases with the increasing level of processing, on going from flowers and leaves (10 4 -10 8 CFU/g), to fruits and seeds (10 2 -10 6 CFU/g), to liquid extracts (10 4 -10 6 CFU/g), and to dry extracts (10 2 -10 5 CFU/g). At the same time the resistivity of microflora to irradiation, expressed as a dose required for the first 90% reduction, increases along the same assortment as 2, 4, 5 and 5 kGy, respectively. This results in doses between 4 and 30 kGy required to treat typical contamination, or between 10 and 40 kGy for severe cases. The contamination of final products, phyto-therapeutic ointments (10 4 -10 7 CFU/g), is relatively sensitive to irradiation (D first 90% red =1 kGy) and usually does not require doses higher than 8 kGy.

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Author

Branka Katušin-Ražem; Boris Novak; Dušan Ražem

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0969-806X)

Published

2001

Language

EN

Field

Materials Science (Physical Sciences)