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Role of polyamines in arginine-dependent colon carcinogenesis in ApcMin/+ mice by Hagit F. Yerushalmi; David G. Besselsen; Natalia A. Ignatenko; Karen A. Blohm-Mangone; Jose L. Padilla-Torres; David E. Stringer; Jose M. Guillen; Hana Holubec; Claire M. Payne; Eugene W. Gerner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Role of polyamines in arginine-dependent colon carcinogenesis in ApcMin/+ mice about?
## Abstract We evaluated the role of polyamines in arginine‐dependent intestinal tumorigenesis in __Apc^Min^__^/+^ mice. Arginine is a substrate for ornithine synthesis and thus can influence polyamine production. Supplementing the diet with arginine increased intestinal and colonic polyamine levels and colonic carcinogenesis. Inhibiting polyamine synthesis with D,L‐α‐diflouromethylornithine (DFMO) decreased small intestinal and colonic polyamine pools. In mice provided basal diet, but not when supplemented with arginine, DFMO decreased small intestinal tumor number and burden, and increased intestinal apoptosis. In mice provided supplemental arginine in the diet, DFMO induced late apoptosis and decreased tumorigenesis in the colon. DFMO slightly reduced tumor incidence, number, and size while significantly decreasing tumor burden and grade. These changes in colon tumorigenesis did not occur in mice not provided supplemental arginine. Our study indicates that polyamines play unique roles in intestinal and colonic carcinogenesis in __Apc^Min^__^/+^ mice. Inhibition of polyamine synthesis suppresses the arginine‐dependent risk of colon tumorigenesis, resulting in apoptosis induction
Who reads Role of polyamines in arginine-dependent colon carcinogenesis in ApcMin/+ mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hagit F. Yerushalmi; David G. Besselsen; Natalia A. Ignatenko; Karen A. Blohm-Mangone; Jose L. Padilla-Torres; David E. Stringer; Jose M. Guillen; Hana Holubec; Claire M. Payne; Eugene W. Gerner
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)