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This study investigated microencapsulating metformin hydrochloride using complex coacervation with soybean protein isolate and pectin. Response surface methodology was used to optimize microcapsule size, size distribution, and encapsulation yield. Under optimized conditions, microcapsules had a mean size of 16 μm, narrow size distribution of 1.3, and highest encapsulation yield of 84%. This method provides controlled release characteristics and heat resistance for metformin hydrochloride microencapsula

Author

boulfissane

Language

EN