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Synthesis of a technetium‐99m labelled L‐tyrosine derivative with the fac ‐^99m^Tc(I)(CO)~3~‐core using a simple kit‐procedure by Ralf Schirrmacher; Slobodan Comagic; Esther Schirrmacher; Frank Rösch is a Medicine article available to read on EtoBox.

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## Abstract The synthesis of a novel technetium‐99m labelled derivative of L‐tyrosine as a potential tumour imaging agent for nuclear medicine diagnosis is reported. The synthesis involved the labelling precursor __fac__‐[^99m^Tc(OH~2~)(CO)~3~]^+^ which was synthesized using the commercially available Isolink^®^‐labelling kit and the tyrosine derivative __O‐(N,N‐bis__(carboxymethyl)aminoethyl)‐L‐tyrosine trifluoroacetate. The labelled compound __O__‐(^99m^Tc(I)‐tricarbonyl‐__N,N‐bis__(carboxymethyl)aminoethyl)‐L‐tyrosine was obtained in a radiochemical yield of 70–80% within 60 min with a radiochemical purity greater than 98% without any HPLC purification step. Purification was achieved merely by solid phase extraction. Chemical as well as chiral purity was determined using gradient‐ and chiral HPLC. Copyright © 2004 John Wiley & Sons, Ltd.

Who reads Synthesis of a technetium‐99m labelled L‐tyrosine derivative with the fac ‐^99m^Tc(I)(CO)~3~‐core using a simple kit‐procedure?

Author

Ralf Schirrmacher; Slobodan Comagic; Esther Schirrmacher; Frank Rösch

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

2004

Language

EN

Field

Medicine (Life Sciences)