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in acute otitis media\* ampici in fai s INVITROt 100% sensitivity. In a recent study of ampicillinresistant Haemophilus isolates, 191 H. influenzae strains were cultured from the middle ear, nasopharynx and throat of children with acute otitis media. All191 of these ampicillin-resistant strains proved sensitive to Bact rim in vitro., Dual action slows resistance. Resistance to ampicillin is now estimated to occur in 18% of all H. influenzae isolates nationwide, with some densely populated areas reporting resistance rates of nearly 40%. 2 The incidence of reported H. influenzae or S. pneumoniae in vitro resistance to Bactrim has been minimal. Dual-action Bactrim attacks susceptible pathogens at two successive steps in their bacterial metabolism. It deprives the bacteria of folate coenzymes, 3 -s and thus retards the development of resistant strains. In vitro studies have shown that bacterial resistance develops more slowly with Bactrim than with either component alone. \*Due to susceptible H . inffuenzae or S. pneumoniae tin vitro activity does not necessarily correlate with clinical results . IN VIVO 93% effective. In two controlled clinical studies of children who had acu te otiti

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Publisher

Walter de Gruyter GmbH

Published

1982

Language

EN

Field

Economics, Econometrics and Finance (Social Sciences)