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Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease by Chih-Hong Wang; Surbhi; Sayhaan Goraya; Jaeman Byun; Subramaniam Pennathur is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Fatty acid handling and complex lipid synthesis are altered in the kidney cortex of diabetic patients. We recently showed that inhibition of the renin-angiotensin system without changes in glycemia can reverse diabetic kidney disease (DKD) and restore the lipid metabolic network in the kidney cortex of diabetic (__db/db)__ mice, raising the possibility that lipid remodeling may play a central role in DKD. However, the roles of specific enzymes involved in lipid remodeling in DKD have not been elucidated. In the present study, we used this diabetic mouse model and a proximal tubule epithelial cell line (HK2) to investigate the potential relationship between long-chain acyl-CoA synthetase 1 (ACSL1) and lipid metabolism in response to fatty acid exposure and inflammatory signals. We found ACSL1 expression was significantly increased in the kidney cortex of __db/db__ mice, and exposure to palmitate or tumor necrosis factor–α significantly increased __Acsl1__ mRNA expression in HK-2 cells. In addition, palmitate treatment significantly increased the levels of long-chain acylcarnitines and fatty acyl CoAs in HK2 cells, and these increases were abolished in HK2 cell lines with specific de

Who reads Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease?

Author

Chih-Hong Wang; Surbhi; Sayhaan Goraya; Jaeman Byun; Subramaniam Pennathur

Publisher

American Society for Biochemistry and Molecular Biology

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)