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Local Overheating of Biotissue Labeled With Upconversion Nanoparticles Under Yb^3+^ Resonance Excitation by Krylov, Ivan V.; Akasov, Roman A.; Rocheva, Vasilina V.; Sholina, Natalya V.; Khochenkov, Dmitry A.; Nechaev, Andrey V.; Melnikova, Nataliya V.; Dmitriev, Alexey A.; Ivanov, Andrey V.; Generalova, Alla N.; Khaydukov, Evgeny V. is a Engineering article available to read on EtoBox.

What is Local Overheating of Biotissue Labeled With Upconversion Nanoparticles Under Yb^3+^ Resonance Excitation about?

Local overheating of biotissue is a critical step for biomedical applications, such as photothermal therapy, enhancement of vascular permeability, remote control of drug release, and so on. Overheating of biological tissue when exposed to light is usually realized by utilizing the materials with a high-absorption cross section (gold, silica, carbon nanoparticles, etc.). Here, we demonstrate core/shell NaYF~4~:Yb^3+^, Tm^3+^/NaYF~4~ upconversion nanoparticles (UCNPs) commonly used for bioimaging as promising near-infrared (NIR) absorbers for local overheating of biotissue. We assume that achievable temperature of tissue labeled with nanoparticles is high enough because of Yb^3+^ resonance absorption of NIR radiation, whereas the use of auxiliary light-absorbing materials or shells is optional for photothermal therapy. For this purpose, a computational model of tissue heating based on the energy balance equations was developed and verified with the experimentally obtained thermal-graphic maps of a mouse in response to the 975-nm laser irradiation. Labeling of biotissue with UCNPs was found to increase the local temperature up to 2°C compared to that of the non-labeled area under the

Who reads Local Overheating of Biotissue Labeled With Upconversion Nanoparticles Under Yb^3+^ Resonance Excitation?

It is typically read by researchers, students, and practitioners in Engineering.

Author
Krylov, Ivan V.; Akasov, Roman A.; Rocheva, Vasilina V.; Sholina, Natalya V.; Khochenkov, Dmitry A.; Nechaev, Andrey V.; Melnikova, Nataliya V.; Dmitriev, Alexey A.; Ivanov, Andrey V.; Generalova, Alla N.; Khaydukov, Evgeny V.
Publisher
Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2013- (ISSN 2296-2646)
Published
2020
Language
EN
Field
Engineering (Physical Sciences)

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