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Nonylphenol Induces the Death of Neural Stem Cells Due to Activation of the Caspase Cascade and Regulation of the Cell Cycle by Chiho Kudo; Koichiro Wada; Tomotake Masuda; Toshimitsu Yonemura; Atsuhito Shibuya; Yohko Fujimoto; Atsushi Nakajima; Hitoshi Niwa; Yoshinori Kamisaki is a Neuroscience article available to read on EtoBox.

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## Abstract Endocrine disruptors (EDs) are a great concern throughout the world, because they have adverse effects on human health and wildlife. In the present study, we investigated the effects of EDs on the proliferation and survival of murine neural stem cells (NSCs). In contrast to bisphenol A, phthalic acid benzyl n‐butyl ester, phthalic acid di‐n‐butyl ester and phthalic acid di(2‐ethylhexyl) ester, the treatment of NSCs with 4‐nonylphenol for 24 h inhibited cell growth in a concentration‐dependent manner. In addition, treatment with 4‐nonylphenol resulted in nuclear condensation and DNA fragmentation (morphological changes due to apoptosis) in NSCs after 12 h of exposure, and activated caspase‐3 after 6 h and 9 h of exposure. Furthermore, an exposure to 4‐nonylphenol led to the accumulation of cells at the G~2~/M phase interface and down‐regulated the protein levels of cyclin A and B1, which are the major regulatory proteins at the G~2~ to M transition of the cell cycle. Together, these results indicate that, in contrast to other EDs, 4‐nonylphenol may exhibit a potent cytotoxicity through apoptosis via the caspase cascade and cell cycle arrest at the G~2~/M phase, and sugge

Who reads Nonylphenol Induces the Death of Neural Stem Cells Due to Activation of the Caspase Cascade and Regulation of the Cell Cycle?

Author

Chiho Kudo; Koichiro Wada; Tomotake Masuda; Toshimitsu Yonemura; Atsuhito Shibuya; Yohko Fujimoto; Atsushi Nakajima; Hitoshi Niwa; Yoshinori Kamisaki

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

2004

Language

EN

Field

Neuroscience (Life Sciences)