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In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains by Guadalupe Miranda-Novales; Blanca E Leaños-Miranda; Mariano Vilchis-Pérez; Fortino Solórzano-Santos is a Medicine article available to read on EtoBox.
What is In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains about?
## Background combinations of drugs has been proposed as an alternative for oxacillin-resistant staphylococci infections, however, limited information about __in vitro__ combinations are available for multi-resistant strains. The objective of this study was to describe the interaction of beta-lactams in combination with vancomycin or amikacin against 26 oxacillin and amikacin-resistant nosocomial __Staphylococcus__ spp. isolates. ## Methods activity of dicloxacillin plus amikacin, cephalothin plus amikacin, cephalothin plus vancomycin, imipenem plus vancomycin and vancomycin plus amikacin was evaluated by checkerboard synergy tests and the fractional inhibitory concentration index (FIC) was calculated. Results: dicloxacillin plus amikacin, and cephalothin plus amikacin were synergistic or partially synergistic in 84.6% and 100% respectively. For nearly half of the isolates the mean concentrations of dicloxacillin, cephalothin and amikacin at which FIC indexes were calculated were achievable therapeutically. Vancomycin plus amikacin had synergistic effect only against two isolates, and partially synergistic in 38.6%. For the combinations vancomycin plus cephalothin and vancomycin pl
Who reads In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains?
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- Author
- Guadalupe Miranda-Novales; Blanca E Leaños-Miranda; Mariano Vilchis-Pérez; Fortino Solórzano-Santos
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2002]-; Springer Science and Business Media LLC; Springer Nature (ISSN 1476-0711)
- Published
- 2006
- Language
- EN
- ISBN
- 9781476071152
- Field
- Medicine (Health Sciences)