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A Single-institution Experience with Concurrent Capecitabine and Radiation Therapy in Gastrointestinal Malignancies by U.N Vaishampayan; E Ben-Josef; P.A Philip; V.K Vaitkevicius; W Du; K.J Levin; A.F Shields is a Medicine article available to read on EtoBox.
What is A Single-institution Experience with Concurrent Capecitabine and Radiation Therapy in Gastrointestinal Malignancies about?
Purpose: We report our clinical experience with 32 patients receiving concurrent irradiation and capecitabine. Methods and Materials: Medical records of patients with gastrointestinal malignancies treated with radiation and capecitabine therapy were reviewed. Results: The population consisted of 20 males and 12 females, with a median age of 67.5 years (45-84 years) and adequate hepatic and bone marrow function. Histology was adenocarcinoma in all patients, except two with esophageal squamous carcinoma. Twenty-one patients received the regimen as adjuvant therapy, three received preoperative therapy, and 8 patients received therapy for palliation. The median dose of capecitabine was 1600 mg/m 2 /day (1200 -2500 mg/m 2 /day) orally for 5 days per week for the duration of radiation therapy. Thirty patients received a total dose ranging from 45 Gy to 64 Gy over 4 -6 weeks. Two previously radiated patients received total doses of 29.9 Gy and 46 Gy. Grade 3/4 toxicities observed were neutropenia in 3 patients and diarrhea, thrombocytopenia, fatigue, and myocardial infarction in 1 patient each. No treatment-related mortality was observed. Twenty of 21 patients (95.2%) who received adjuvan
Who reads A Single-institution Experience with Concurrent Capecitabine and Radiation Therapy in Gastrointestinal Malignancies?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- U.N Vaishampayan; E Ben-Josef; P.A Philip; V.K Vaitkevicius; W Du; K.J Levin; A.F Shields
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)