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Left ventricular circumferential strain and coronary microvascular dysfunction: A report from the Women's Ischemia Syndrome Evaluation Coronary Vascular Dysfunction (WISE-CVD) Project by Balaji Tamarappoo; T. Jake Samuel; Omeed Elboudwarej; Louise E.J. Thomson; Haider Aldiwani; Janet Wei; Puja Mehta; Susan Cheng; Behzad Sharif; Ahmed AlBadri; Eileen M. Handberg; John Petersen; Carl J. Pepine; Michael D. Nelson; C. Noel Bairey Merz is a Medicine article available to read on EtoBox.

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## Aims: Women with ischemia but no obstructive coronary artery disease (inoca) often have coronary microvascular dysfunction (cmd). left ventricular (lv) circumferential strain (cs) is often lower in inoca compared to healthy controls; however, it remains unclear whether cs differs between inoca women with and without cmd. we hypothesized that cs would be lower in women with cmd, consistent with cmd-induced lv mechanical dysfunction. ## Methods and results: Cardiac magnetic resonance (cmr) images were examined from women enrolled in the women's ischemia syndrome evaluation-coronary vascular dysfunction project. cs by feature tracking in inoca women with cmd, defined as myocardial perfusion reserve index (mpri) <1.84 during adenosine-stress perfusion cmr, was compared with cs in women without cmd. in a subset who had invasive coronary function testing (cft), the relationship between cs and cft metrics, lv ejection fraction (lvef) and cardiovascular risk factors was investigated. among 317 women with inoca, 174 (55%) had cmd measured by mpri. cs was greater in women with cmd compared to those without cmd (23.2 ± 2.5% vs. 22.1 ± 3.0%, respectively, p = 0.001). in the subset with cft

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Author

Balaji Tamarappoo; T. Jake Samuel; Omeed Elboudwarej; Louise E.J. Thomson; Haider Aldiwani; Janet Wei; Puja Mehta; Susan Cheng; Behzad Sharif; Ahmed AlBadri; Eileen M. Handberg; John Petersen; Carl J. Pepine; Michael D. Nelson; C. Noel Bairey Merz

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)