Can I read New phenotypes of serum ? 1-antitrypsin in Japanese detected by gel slab isoelectric focusing on EtoBox?

New phenotypes of serum ? 1-antitrypsin in Japanese detected by gel slab isoelectric focusing by Shoji Harada; Kazuhiko Miyake; Hiroshi Suzuki; Toshitsugu Oda is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is New phenotypes of serum ? 1-antitrypsin in Japanese detected by gel slab isoelectric focusing about?

The phenotype distribution and gene frequencies of serum a~antitrypsin in 856 healthy blood donors in Tokyo were examined by gel slab isoelectric focusing (pH 4--6). The allele of the common subtype variant Pi M2 was present with a frequency of 0.1099 in Japanese. A study of 23 twin pairs and their parents was in agreement with the hypothesis of autosomal codominant inheritance of Pi M subtypes. Other rare variant alleles, Pi M F, Pi M s, Pi M ~, Pi M v, Pi M x, Pi M z were found in very low frequencies. The total concentration of serum a~-antitrypsin was compared among three different phenotypic groups (M1, MIM2, M2). Statistically significant quantitative differences were found among these three groups (P< 0.01).

Who reads New phenotypes of serum ? 1-antitrypsin in Japanese detected by gel slab isoelectric focusing?

Author

Shoji Harada; Kazuhiko Miyake; Hiroshi Suzuki; Toshitsugu Oda

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-6717)

Published

1977

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)