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Can I read Self-Homeostasis Immunoregulatory Strategy for Implant-Related Infections through Remodeling Redox Balance on EtoBox?
Self-Homeostasis Immunoregulatory Strategy for Implant-Related Infections through Remodeling Redox Balance by Dongdong Xu; Wanbo Zhu; Cheng Ding; Jiawei Mei; Jun Zhou; Tao Cheng; Geyong Guo; Xianlong Zhang is a Engineering article available to read on EtoBox.
What is Self-Homeostasis Immunoregulatory Strategy for Implant-Related Infections through Remodeling Redox Balance about?
Implant-related infections (IRIs) are catastrophic complications after orthopedic surgery. Excess reactive oxygen species (ROS) accumulated in IRIs create a redox-imbalanced microenvironment around the implant, which severely limits the curing of IRIs by inducing biofilm formation and immune disorders. However, current therapeutic strategies commonly eliminate infection utilizing the explosive generation of ROS, which exacerbates the redox imbalance, aggravating immune disorders and promoting infection chronicity. Herein, a self-homeostasis immunoregulatory strategy based on a luteolin (Lut)-loaded copper (Cu 2+ )-doped hollow mesoporous organosilica nanoparticle system (Lut@Cu-HN) is designed to cure IRIs by remodeling the redox balance. In the acidic infection environment, Lut@Cu-HN is continuously degraded to release Lut and Cu 2+ . As both an antibacterial and immunomodulatory agent, Cu 2+ kills bacteria directly and promotes macrophage proinflammatory phenotype polarization to activate the antibacterial immune response. Simultaneously, Lut scavenges excessive ROS to prevent the Cu 2+ -exacerbated redox imbalance from impairing macrophage activity and function, thus reducing Cu
Who reads Self-Homeostasis Immunoregulatory Strategy for Implant-Related Infections through Remodeling Redox Balance?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Dongdong Xu; Wanbo Zhu; Cheng Ding; Jiawei Mei; Jun Zhou; Tao Cheng; Geyong Guo; Xianlong Zhang
- Publisher
- American Chemical Society (ACS)
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)