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Evaluation of Microvascular Changes in the Retina and Choriocapillaris in Primary Glaucoma and Neuromyelitis Optica Spectrum Disorder with Optical Coherence Tomography Angiography by Ying Li; Wenhui Liu; Yan Yan; Chen Wang; Hui Guo is a Medicine article available to read on EtoBox.

What is Evaluation of Microvascular Changes in the Retina and Choriocapillaris in Primary Glaucoma and Neuromyelitis Optica Spectrum Disorder with Optical Coherence Tomography Angiography about?

Background To assess quantitatively the microvascular changes in the retina and choroid of healthy eyes, eyes of subjects with primary angle-closure glaucoma (PACG), primary open-angle glaucoma (POAG) and neuromyelitis optica spectrum disorder (NMOSD) using optical coherence tomography angiography (OCTA). Methods A series of healthy individuals and subjects with PACG, POAG and NMOSD were recruited in this cross-sectional study. OCTA was performed to capture the optic nerve head and macula images and the vessel density (VD) and retinal nerve fiber layer (RNFL) thickness were quantified. The choriocapillary flow density (CFD) was calculated as the percentage of flow area to the whole selected area. Results A total of 68 PACG subjects, 25 POAG subjects, 51 NMOSD subjects and 37 healthy controls were enrolled. Significant decreases in peripapillary VD and RNFL thickness were observed in PACG (p < 0.001) and POAG (p < 0.001) eyes and also in NMOSD subjects with an optic neuritis history (p < 0.001) compared with healthy controls. Unaffected eyes in PACG and POAG subjects had lower baseline peripapillary VD than healthy controls (p = 0.002 and p = 0.011, respectively). PACG eyes showed a

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Author

Ying Li; Wenhui Liu; Yan Yan; Chen Wang; Hui Guo

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)