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Abnormal cerebral metabolism in polydrug abusers during early withdrawal: A ^31^P MR spectroscopy study by James D. Christensen; Marc J. Kaufman; Jonathan M. Levin; Jack H. Mendelson; B. Leonard Holman; Bruce M. Cohen; Perry F. Renshaw is a Medicine article available to read on EtoBox.

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## Abstract Phosphorus magnetic resonance spectroscopy (^31^P MRS) at 1.5 T was performed on nine polysubstance abusing men. All nine patients met DSM‐III‐R criteria for concurrent cocaine and heroin dependence, were neurologically normal, were negative for the human immunodeficiency virus, and had normal clinical brain MRI scans. Patients were scanned 2‐7 days after admission to a drug treatment unit. Eleven age‐matched control subjects also were studied. The ISIS localized phosphorus spectra were obtained from a 5‐cm thick axial brain slice and a 100‐cc white matter volume. In the brain slice, the phosphorus metabolite signal expressed as a percentage of total phosphorus signal was 15% higher for phosphomonoesters, 10% lower for nucleotide triphosphates (β‐NTP), and 7% lower for total nucleotide phosphates in polydrug abusers compared with those in controls. Phosphodiesters, inorganic phosphate, phosphocreatine, total phosphorus, pH, and free magnesium concentration were unchanged. None of these parameters correlated with the methadone dose or the number of days abstinence. Single photon emission computed tomographic imaging of a subgroup of the patients revealed abnormal cerebra

Who reads Abnormal cerebral metabolism in polydrug abusers during early withdrawal: A ^31^P MR spectroscopy study?

Author

James D. Christensen; Marc J. Kaufman; Jonathan M. Levin; Jack H. Mendelson; B. Leonard Holman; Bruce M. Cohen; Perry F. Renshaw

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

1996

Language

EN

Field

Medicine (Health Sciences)