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Antibacterial and anti‐inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo by Guisong Gu; Deniz Eren Erişen; Ke Yang; Bingchun Zhang; Minggang Shen; Jingyu Zou; Xun Qi; Shanshan Chen; Xiaohe Xu is a Medicine article available to read on EtoBox.
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## Abstract Copper ions (Cu) grafted chitosan coating was prepared using the pneumatic spraying method on the silicone rubber surface. Coating's surface properties, morphology, composition, Cu releasing behavior, antibacterial, and anti‐inflammatory activities are investigated and discussed. Surface properties, composition, and morphology were investigated by scanning electron microscopy (SEM) and contact angle measurements. The antibacterial activity has been tested with Escherichia coli and Staphylococcus aureus suspensions in vitro. Besides, the morphology of the biofilm was inspected with a field emission SEM. To evaluate the anti‐inflammatory activity and biosafety of the coating in vivo, the optimized coating samples and control groups were implanted subcutaneously into the back of mice. The bacterial environment model was established by injection of the bacterial suspension. The morphology and bacterial adhered on the surface of catheters and the surrounding tissues were analyzed after 5 days of implantation. As in vitro results, the number of adhered bacterial on the surface of the silicon rubber surface was decreased, and the anti‐inflammatory rate was increased by the int
Who reads Antibacterial and anti‐inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo?
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- Author
- Guisong Gu; Deniz Eren Erişen; Ke Yang; Bingchun Zhang; Minggang Shen; Jingyu Zou; Xun Qi; Shanshan Chen; Xiaohe Xu
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)